improving solubility by ball milling

  • A top-down technique to improve the solubility and ...

    2017-7-11 · Wet milling technique utilizes ball milling using milling media ... It has log P-value of 2.170. 24 Scientists have worked on improving the solubility of ACF by various approaches like solid dispersion, 9, 25 cyclodextrin complexes, 26, 27 chitosan nanoparticles, 28 and nanocrystals. 29, 30 Recently, ...

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  • Overview of milling techniques for improving the ...

    2015-7-1 · Ball milling of pure drug mixtures have also been investigated. More recently, ball milling of a combination of two BCS Class II drugs, simvastatin and glipizide, resulted in the formation of stable co-amorphous mixtures . Despite the efficiency of ball milling for size reduction or amorphization, it is less amendable to scale up.

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  • (PDF) Overview of milling techniques for improving the ...

    2015-2-17 · Overview of milling techniques for improving the solubility of poorly water-soluble drugs. February 2015; Asian Journal of Pharmaceutical Sciences

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  • Improvement in solubility of poor water-soluble drugs by ...

    2022-1-12 · The solubility of a drug is intrinsically related to the particle size. Reduction of particle size of a drug by various means such as jet mill, rotor stator colloidal mill, ball mill, etc. leads to increase in surface area with enhanced dissolution.

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  • A top-down technique to improve the solubility and ...

    The results obtained indicated that the developed nanocrystals of aceclofenac were successful in improving the solubility, thus the absorption and bioavailability of the drug. Hence, it may be a viable and cost-effective alternative to the current therapy. Keywords: aceclofenac, nanocrystals, ball milling, QbD, DoE, box-behnken design

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  • Technologies to Improve the Solubility, Dissolution and ...

    2017-12-4 · Micronization of drugs is done by milling techniques using Jet mill, Ball mill, Rotor-stator colloid mill, etc. This approach can reduce particle sizes down to 1 micron. Micronization improved the digestive absorption, and consequently the

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  • Solubility and magnetic properties enhancement in bi

    In order to improve solubility and magnetic properties, the ball milling technology was used for the production of 50Cu–40Fe–10Mn (wt%) alloy.

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  • A top-down technique to improve the solubility and ...

    Hence size reduction technique by a top-down approach using wet milling process was utilized to improve the solubility and, consequently, the dissolution velocity of aceclofenac. The quality of the final product was ensured by Quality by Design approach wherein the effects of critical material attributes and critical process parameters were ...

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  • Ball-milling is an effective pretreatment of glycosylation ...

    Theoretically speaking, ball-milling alters protein structure, which is beneficial to increasing the degree of glycosylation and thus enhances the modification effect. So EWP was modified by dry ball-milling pretreatment assisted wet glycosylation in this paper, hoping to further improve the functional properties of EWP.

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  • [PDF] Effect of Cr to Fe on the Solid Solubility, Lattice ...

    2014-10-1 · -Fe-Cr phase was investigated using formula Fe80Cr20. Ball milling process and ultrasonic technique is successfully done to develop solid solubility and improve homogenous, respectively. However, the effect of the Cr to Fe powder is not complete investigated using combination of its process. Ball milling is conducted by milling time of 60 hours and ultrasonic

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  • (PDF) Overview of milling techniques for improving the ...

    2015-2-17 · Overview of milling techniques for improving the solubility of poorly water-soluble drugs. February 2015; Asian Journal of Pharmaceutical Sciences 19(4) ... Schematic diagram of a ball mill. The ...

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  • Technologies to Improve the Solubility, Dissolution and ...

    2017-12-4 · Micronization of drugs is done by milling techniques using Jet mill, Ball mill, Rotor-stator colloid mill, etc. This approach can reduce particle sizes down to 1 micron. Micronization improved the digestive absorption, and consequently the

    Chat Online
  • A top-down technique to improve the solubility and ...

    2017-7-11 · Wet milling technique utilizes ball milling using milling media ... It has log P-value of 2.170. 24 Scientists have worked on improving the solubility of ACF by various approaches like solid dispersion, 9, 25 cyclodextrin complexes, 26, 27 chitosan nanoparticles, 28 and nanocrystals. 29, 30 Recently, ...

    Chat Online
  • Solubility and magnetic properties enhancement in bi

    In order to improve solubility and magnetic properties, the ball milling technology was used for the production of 50Cu–40Fe–10Mn (wt%) alloy.

    Chat Online
  • ENHANCEMENT OF SOLUBILITY AND DISSOLUTION

    2021-10-23 · solubility and dissolution of drugs that are poorlysoluble. Solid dispersions (SDs) of BCS-II drugs were prepared by ball milling in tio ra of drug:polymer i.e.curcumin:porous starch (1:0.5, 1:1, 1:2 and . 1:3)Further, SDs were investigated by solubility, FTIR, XRD, DSC,micromeritics, nd a in-vitro dissolution. .

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  • Evaluation of Drug–Polymer Solubility Curves Through ...

    2014-10-31 · Using ball milling, it was possible to obtain solubility data in the entire measured temperature interval. However, as the T g of the demixed material did not change after annealing from the spray‐dried and film‐casted mixtures at 150°C, the concentration of IMC in PVP K12 (85:15, w/w) was considered below the equilibrium solubility and ...

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  • [PDF] Effect of Cr to Fe on the Solid Solubility, Lattice ...

    2014-10-1 · -Fe-Cr phase was investigated using formula Fe80Cr20. Ball milling process and ultrasonic technique is successfully done to develop solid solubility and improve homogenous, respectively. However, the effect of the Cr to Fe powder is not complete investigated using combination of its process. Ball milling is conducted by milling time of 60 hours and ultrasonic

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  • Ball-milling is an effective pretreatment of glycosylation ...

    2021-11-30 · In order to further improve the functional properties of egg white protein powder (EWP), the effects of ball-milling pretreatment on the functional properties of EWP by glycosylation modification were studied. The results manifested that glycosylation ...

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  • Nanosuspension with improved saturated solubility and ...

    2022-1-4 · Preparation of Cilostazol (CLZ) nanosuspension to improve its solubility. Composition of the nanosuspension and the milling parameters were optimized by DoE. Solidification of nanosuspension to perform matrix pellets. Size reduction and amorphization increased dissolution rate of CLZ. Solid state characterization of matrix pellets via DSC and PXRD.

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  • Enhancing Solubility of Candesartan Cilexetil by Co ...

    2017-3-30 · Zhi HL, Samanta AK, Heng PWS. Overview of milling techniques for improving the solubility of poorly water-soluble drugs. Asian J Pharm Sci 2015;10:255-74. Dushkin AV, Meteleva ES, Tolstikova TG. Mechanochemical preparation and pharmacological activities of water-soluble intermolecular complexes of arabinogalactan with medicinal agents.

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  • A top-down technique to improve the solubility and ...

    Hence size reduction technique by a top-down approach using wet milling process was utilized to improve the solubility and, consequently, the dissolution velocity of aceclofenac. The quality of the final product was ensured by Quality by Design approach wherein the effects of critical material attributes and critical process parameters were ...

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  • Enhancement of Solubility and Dissolution Rate of

    The purpose of the present attempt is to prepare a solid dispersion of curcumin and porous starch in order to increase the solubility and dissolution of drugs that are poorlysoluble. Solid dispersions (SDs) of BCS-II drugs were prepared by ball milling in ratio of drug: polymer i.e. curcumin: porous starch (1:0.5, 1:1, 1:2 and 1:3).

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  • Study on the Effect of Polymer Excipients on the ...

    2022-1-3 · Although the preparation of amorphous solid dispersions can improve the solubility of crystalline drugs, there is still a lack of guidance on the micromechanism in the screening and evaluation of polymer excipients. In this study, a particular method of experimental characterization combined with molecular simulation was attempted on solubilization of

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  • Ternary Solid Dispersion Strategy for Solubility ...

    2021-2-5 · Amorphous ternary solid dispersion has become one of the strategies commonly used for improving the solubility and bioavailability of poorly water soluble drugs. Such multicomponent solid dispersion can be obtained by different techniques, this chapter provides an overview of ternary solid dispersion by co-milling method from the perspectives of physico-chemical

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  • Use of Co-Milling to Improve Physical Stability of ...

    2008-11-10 · Excipients are added to a drug formulation to enhance the manufacture process or product quality, e.g. improving tablet compactibility, solubility or bioavailability[5]. However, the milling process also induces structural disorders leading to the formation of amorphous regions, particularly at the surfaces of the particles[6].

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  • Improving co-amorphous drug formulations by the

    2014-7-14 · Co-milling of TRP–PRO resulted in a co-amorphous mixture, suggesting interactions between the two amino acids (Figure 1). Ball milling of the ternary mixture, NAP–TRP–PRO, resulted in an amorphous blend (Figure 1). Thus, the addition of PRO had a positive effect on the amorphization of NAP, which could not be achieved by any of the amino ...

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  • A review on solubility enhancement methods for poorly ...

    Solubility has a significant effect on drug efficacy. The solubility of a drug in water is a basic property that must be considered. The pharmacokinetic profile is important, especially for drugs with low solubility. Drugs taken orally will have a lower number of active drug compounds in the systemic circulation if the drug has low solubility, which also affects the bioavailability of the drug.

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  • Amelioration effects of coastal saline-alkali soil by ball

    2021-12-4 · Herein, a novel biochar (BPBC) was successfully prepared by ball milling and red phosphorus (P) loading. Ball milling could effectively grind pristine biochar into submicron particles, load uniform and nanoscale P-containing particles on biochar, and hence markedly improve the special surface area, P loading amount, and P-containing functional groups contents.

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  • Polymers | Free Full-Text | Solubility Improvement of ...

    2020-4-7 · The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC), hydroxypropyl methylcellulose acetate succinate (HPMCAS), microcrystalline cellulose (MCC),

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  • Ball milling - Digitalfire

    Ball milling is normally done in consort with wet screening and/or roller-milling/air floating, for example, so that large particles have already been removed by the time the material reaches the ball mill. Air floating can also be done in consort with dust ball milling.

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